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CovalAb S.A.R.L

Activité

In the biotechnology industry where the creation of any start-up depends on the input of the investors and on the fluctuations of the stock market, Covalab stands out as an exception.
Indeed, with a minimum of initial capital and the assistance of University Claude Bernard (Lyon), the company developed slowly using as its foundation its know-how in Immunochemistry.

Covalab principal activity, which has allowed it to attain complete financial independence, is that devoted to the development of monoclonal & polyclonal antibodies destined for research, diagnosis and therapeutics.

Some of the antibodies developed for pharmaceutical companies are among products having a strong potential for clinical application. Covalab also has its own wide range of products for research and diagnosis in areas as varied as cancer, neuroscience, auto-immune diseases, to mention only a few.

* In biomedicine, the service activity of Covalab represents but the tip of the scientific and technical iceberg which the team at Covalab has put together. Indeed, the scientists at Covalab have more than 20 years of experience in the chemical modification of antigens and antibodies destined for diagnosis and therapy.

A list, by no means complete of some of their achievements, includes the production of :
- antibodies directed against new tumour markers
- antibodies as gene vectors in cancerology
- antibodies kits for detecting patients with cerebral protein aggregates in neurology
- diagnostic kits for detecting patients with autoimmune disease such as rheumatoid arthritis and celiac disease.

* In agro food, the development of complete diagnostic kits including the antibodies and the chemically modified immunogens for the detection of mycotoxins, phycotoxins, pesticides and polyaromatic hydrocarbons.

Domaines d'application

• IAA (Industrie Agro-alimentaire)
• Santé Humaine

Technologies utilisées

• Anticorps monoclonaux
• Bio-réacteur
• Bioprocess
• Diagnostic
• Isolation de peptide et synthèse
• Protéomique
• Purification - Séparation
• Synthèse de molécules
• Système de délivrance (vecteurs, galénique)

Coordonnées

Siège de l'entreprise en France
11 Avenue Albert Einstein
69100 VILLEURBANNE
FRANCE
Tél. : 04 37 65 42 30
Fax : 04 37 28 94 16
E-mail : enquiries@covalab.com
Site : www.covalab.com

Informations juridiques

Statut : Société à responsabilité limitée
Code NAF : 2120Z
N° SIREN : 40183226600050
Date de création : 01/08/1995

Personnes référencées

Responsable, PDG, Directeur : Saïd EL ALAOUI

Publications

Anti-protein service:
- Brophy, T.M. et al. RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. Biochem Biophys Res Commun 369, 1088-93(2008).
- Lecroisey, C. et al. DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1. Mol Biol Cell 19, 785-96(2008).

Anti-peptide service:
- Naba, A. et al. Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J 27, 38-50(2008).
- Rogemond, V. et al. Processing and nuclear localization of CRMP2 during brain development induce neurite outgrowth inhibition. J Biol Chem 283, 14751-61(2008).
- Navarro, F.P. et al. Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. J Neurochem 105, 34-45(2008).
- Rancès, E. et al. Genetic and functional characterization of the type IV secretion system in Wolbachia. J Bacteriol 190, 5020-30(2008).
- Grasa, P. et al. The pattern of localization of the putative oocyte activation factor, phospholipase Czeta, in uncapacitated, capacitated, and ionophore-treated human spermatozoa. Hum Reprod 23, 2513-22(2008).
- Carrouel, F. et al. HUGO (FNDC3A): a new gene overexpressed in human odontoblasts. J Dent Res 87, 131-6(2008).
- Young, C. et al. Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction. Fertil Steril (2008).doi:S0015-0282(08)01125-4
- Omi, N. et al. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res 86, 828-34(2008).
- Levillain, O. et al. L-arginine metabolism in dog kidney and isolated nephron segments. Metabolism 57, 9-23(2008).
- Cheillan, D. et al. Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice. Mol Genet Metab 94, 135-8(2008).
- Sousa, C. et al. Colocalization Analysis of PPP1 Isoforms and Two Novel Targeting Subunits in Breast Carcinoma. Microscopy and Microanalysis 14, 134-136(2008).
- Sousa, C. et al. Subcellular Localization of a Novel Alternative Splicing of IIIG9 and Colocalization with PPP1gamma Isoforms. Microscopy and Microanalysis 14, 141-143(2008).

Products:
- Toscano, F. et al. P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. Oncogene 27, 4161-71(2008).
- Boileau, C. et al. Intracellular localisation of galectin-3 has a protective role in chondrocyte survival. Ann Rheum Dis 67, 175-81(2008).
- Maiuri, L. et al. Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation. J Immunol 180, 7697-705(2008).
- Rogemond, V. et al. Processing and nuclear localization of CRMP2 during brain development induce neurite outgrowth inhibition. J Biol Chem 283, 14751-61(2008).
- Kizawa, K. et al. Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle. J Biol Chem 283, 5004-13(2008).
- Shweke, N. et al. Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol 173, 631-42(2008).
- Thibaut, S. et al. Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding? J Invest Dermatol (2008).doi:jid2008231
- Wang, D. et al. Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathology. J Alzheimers Dis 13, 53-66(2008).
- Dai, Y. et al. Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor stimulation. J Pharmacol Exp Ther 326, 153-62(2008).
- Mashima, H. et al. Involvement of vesicle-associated membrane protein 7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA. Infect Immun 76, 2296-303(2008).
- Joly-Pharaboz, M. et al. Androgen inhibits the growth of carcinoma cell lines established from prostate cancer xenografts that escape androgen treatment. J Steroid Biochem Mol Biol 111, 50-9(2008).
- Roncoroni, L. et al. Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line. Liver Int (2008).doi:LIV1749
- Brevé, J.J.P. et al. Validated sandwich ELISA for the quantification of tissue transglutaminase in tissue homogenates and cell lysates of multiple species. J Immunol Methods 332, 142-50(2008).
- Lysitsa, S. et al. COX-2 expression in oral lichen planus. Dermatology 217, 150-5(2008).
Hatterer, E. et al. Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions. PLoS ONE 3, e3321(2008).
- Bergstrand, A. et al. Towards a biosensor immunoassay of protein-bound isopeptides in human plasma. Colloids Surf B Biointerfaces 66, 150-3(2008).

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fiche mise à jour le 17/11/2009 par Vincent THOMAS

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